Lapii GA, Yakovleva AY, Neimark AI, Lushnikova EL.
Bull Exp Biol Med. 2017 Jun;163(2):280-283. doi: 10.1007/s10517-017-3784-0

The expression of Ki-67 proliferation marker was studied in vaginal biopsy specimens from women with stress urinary incontinence treated using a Fotona nonablative erbium laser. Cells expressing Ki-67 were located in all cases in the parabasal and basal levels of stratified squamous epithelium, the index of labeled nuclei before Er:YAG laser exposure was 19.05±2.86%. After 1-2 months of laser therapy, the index of labeled nuclei in the epithelium increased significantly and reached 31.79±2.25%. These changes were interpreted as a result of epithelial-stromal interactions. Presumably, the increase in proliferative activity of the vaginal epithelium after exposure to Er:YAG laser was due to the presence of an appreciable level of synthetically active fibroblasts in the subepithelial stroma.

Keywords: Fotona Er:YAG laser; epithelial proliferative activity; immunohistochemistry; stress incontinence; vaginal biopsy.

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